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KMID : 0043320150380061190
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Archives of Pharmacal Research
2015 Volume.38 No. 6 p.1190 ~ p.1203
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Artesunate inhibits proliferation of naive CD4+ T cells but enhances function of effector T cells
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Lee Sung-Ho
Cho Young-Chang
Kim Kyung-Hee
Lee Ik-Soo
Choi Hyun-Jin
Kang Bok-Yun
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Abstract
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Artesunate is an artemisinin derivative from Artemisia annua and is being applied as a first-line drug for malaria treatment. In addition to anti-malarial effects, anti-cancer, anti-viral, and anti-inflammatory activities have been reported for artemisinin derivatives. In this study, we investigated the effects of artesunate on naive T cell activation and Th1/Th2 differentiation. Artesunate inhibited the proliferation of CD4+ T cells and the production of IL-2, T cell growth factor. Moreover, artesunate reduced the expression of cell surface protein CD25 (IL-2 receptor alpha chain) and CD69 on CD4+ T cells. Artesunate showed inhibitory effects on naive T cell activation but artesunate increased the production of IFN-γ and IL-4 under Th1 and Th2 skewed condition respectively. Therefore, these results suggest that artesunate has a negative mitogenic effect on CD4+ T cells but reinforces the function of effector T cells.
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KEYWORD
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Artesunate, CD4+ T cell, Proliferation, Differentiation, Cytokine
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